A New Way to Administer Epinephrine – Introducing neffy®

ARS Pharmaceuticals Operations has recently introduced neffy® 2 mg, the first and only FDA-approved needle-free way to administer epinephrine. neffy® is a nasal spray used for emergency treatment of severe allergic reactions in adult and pediatric patients who weigh at least 66 pounds (30 kg). Per DailyMed, “the recommended dosage of neffy® is one spray (2 mg) administered in one nostril. In the absence of clinical improvement or if symptoms worsen after the initial treatment, a second dose of neffy® may be administered in the same nostril with a second nasal spray starting 5 minutes after the first dose.

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PAAS Tips:

  • neffy® is for intranasal use only
  • neffy® should NOT be primed
  • 1 box (2 devices) is billed as 2 each
  • Each box contains two single use devices each containing one dose (2 mg) of epinephrine
  • A 1-day supply would be appropriate for billing purposes as it is recommended that patients are always prescribed, and have immediate access to, two neffy® nasal spray devices
  • Refer to our updated Nasal Inhaler Chart on the Member Portal
  • Pharmacies can utilize our 2024 Self-Audit Series #10: Nasal and Oral Inhaler Prescriptions to check for accuracy and consistency

Jennifer Ottman, CPhT